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John Francis Daley

Jonathan Goldstein

Ed Helms Rusty Griswold

Christina Applegate Debbie Griswold

Skyler Gisondo James Griswold

Steele Stebbins Kevin Griswold

Chris Hemsworth Stone Crandall

Leslie Mann Audrey Griswold

Chevy Chase Clark Griswold

Beverly D'Angelo Ellen Griswold

Charlie Day Chad

Catherine Missal Adena

Ron Livingston Ethan

Norman Reedus Trucker

Keegan-Michael Key Jack Peterson

Regina Hall Nancy Peterson

Emyri Crutchfield Sheila Peterson

Alkoya Brunson Gary Peterson

Nick Kroll Colorado Cop

Tim Heidecker Utah Cop

Kaitlin Olson Arizona Cop

Michael Peña New Mexico Cop

Hannah Jeter Ferrari Girl

David Clennon Harry Co-Pilot

Colin Hanks Jake

Kirstin Ford Mom on Plane

Ethan Maher Boy on Plane

Elizabeth Gillies Heather

Cristina Squyres Brooke

Nadine Avola Chelsea

Ryan Cartwright Terry

Valerie Payton Shuttle Driver

O'Clair Alexander Husky Lady at Monument

Miles Doleac Man on the Monument

Holly Gardner Women at Monument

R.F. Daley Furious Husband

Elizabeth Fendrick Furious Wife

Michael H. Cole Male Guest

Brooke Jaye Taylor Female Guest

Matthew Cornwell Male Guest #2

Mitchell Warren Wally World Kid #2

John Francis Daley Ride Operator

Brandon Michael Hale Gas Station Clerk (uncredited)

Libby Blake Boobs (uncredited)

Rick Ericson Hawaiian (uncredited)

Omar Lagudali Reporter (uncredited)

Cameron McIntyre Young James (age 7 / 9) (uncredited)

Jonathan Goldstein Hot Tub Guy (uncredited)

John C. McGinley Motorbike Cop